Enhanced Retinol Smoothing Serum 5x (30 ml)


This moisturizing therapeutic facial serum helps to build up the skin matrix for smoother, firmer skin thereby diminishes fine lines, wrinkles and achieves more evenly toned skin. This clinically proven retinol serum pairs a time-released delivery system with soothing green tea polyphenols to provide the effectiveness of a retinoid without the irritation.

Fragrance-free Oil-free Gluten-free Non- comedogenic Sensitive skin friendly



Unique Micro Polymer Delivery System stabilizes and protects to continuously and efficiently drive retinol into skin

All-trans-Retinol helps increase cell turnover, supports healthy collagen production and brighten areas of hyperpigmentation, it also has anti-acne properties especially in the treatment of comedonal acne.

90% Green Tea Polyphenols calm and soothe skin back to its natural state while neutralizing free radicals

Hyaluronic Acid provides essential hydration while helping to maintain the skin barrier function

Caffeine enhances overall antioxidant activity and diminishes visible redness

How To Use

Avoiding eye area, apply 3-4 pumps to clean skin once a day, in the evening or as directed by your physician


Because of its exfoliative properties, it is sometimes normal for skin to peel when starting to use Retinol for the first time. It is advisable to start with the lower Retinol concentration and increase to the higher concentration as skin tolerates.

Can reduce frequency of use to alternate days if peeling is intolerable.

Though these Retinol serums are moisturizing, if skin feels too tight, wait 5 to 10 minutes after application, then apply a moisturizer.


All-trans-Retinol, 90% Green Tea Polyphenols, Caffeine, Hyaluronic Acid

Complete Your Regimen

As part of an Anti-acne Regimen
Combination treatments are the best way to control acne. For best results, wash with one of the strengths of the 101 Clinical skincare Oxygen Acne Wash or 101 Clinical skincare Hydroxy Acne Wash in the morning and night. Then apply either the 101 Clinical skincare Hydroxy Acne spray 10/2 or 101 Clinical Skincare Oxygen Acne 2.5% gel respectively as a morning treatment before your sun protection.

As part of an Anti-aging/Facial Repair Regimen
Combination treatments are also the best way to stimulate collagen and elastin in an anti-aging/ skin repair regimen. Wash morning and evening with our 101 clinical skincare Smoothing and Moisturizing glycolic acid face & body cleanser 10% or the 101 Clinical skincare Ultra-gentle cleansing wash. As a morning anti-aging treatment, use our 101 clinical skincare Powerful Trio Anti-oxidant serum or 101 Clinical skincare Premium Vitamin C Serum 20% (if brightening is needed) before your sun protection. At night use our 101 Clinical skincare Intense Nourishing Night therapy which has intense moisturizing properties alongside its anti-aging properties, especially if the retinol serum is too drying.

As part of an Uneven skin/Skin Brightening Regimen
Combination treatments are very beneficial in treating uneven skin tone and overall brightening of the skin. Complement this Retinol serum by washing morning and evening with the 101 Clinical skincare Smoothing & Moisturizing Glycolic acid face & body cleanser 10%, then exfoliating 2 to 3 times weekly with the 101 Clinical Skincare Brightening micro-beaded polish. Use the 101 Clinical Skincare Botanical Brightening kit pads morning and evening, before sun protection in the morning and before the retinol serum at night.

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